Karen R. Jonscher is an Associate Professor of Anesthesiology at the University of Colorado Anschutz Medical Campus. She completed her B.S. in Engineering Physics at the University of Colorado in Boulder and earned her Ph.D. in Applied Physics at the California Institute of Technology in Pasadena, CA. Her graduate work focused on development of hardware solution in the newly emerging field of proteomics and biological mass spectrometry. In her post-doctoral studies and work following at the National Jewish Medical Center and the University of Colorado, Dr. Jonscher continued to work in the proteomics arena and directed a core facility for a number of years, assisting researchers world-wide with using mass spectrometry and proteomics to address biomedical questions. More recently she has transitioned into independent biomedical research herself, and has focused on the role of maternal obesity on offspring metabolic dysfunction and the use of anti-oxidants and sirtuin 3 in protecting from liver disease in offspring. Her initial manuscript on the role of sirtuin 3 in obesity was the “Most Downloaded Paper” in Biochemical Journal in 2014. Karen has always had an underlying interest in space. As an undergraduate she participated in two internships; one at Caltech focused on modeling the production of the atmosphere around Io and one at Lockheed Martin in Titan IV Mission Operations. Recently, Dr. Jonscher was able to link her expertise in the liver and interest in space by analyzing liver tissues from mice flown aboard STS-135. She hopes to extend her findings to additional models and apply what she learns to protect astronaut health as well as health of individuals subjected to bedrest on Earth.